By Privatdozentin Dr. med. Ursula Creutzig (auth.), Privatdozentin Dr. med. Ursula Creutzig, Professor Dr. med. Jörg Ritter, Professor Dr. med. Günther Schellong (eds.)
The result of remedy for early life acute myelogenous leukemia (AML) have greater significantly over the past ten years. This growth was once validated by means of the 2 consecutive multicenter reports, AML-BFM-78 and -83, within which nearly exact prolonged multi drug regimes of che motherapy have been administered for 8 weeks and up by means of years upkeep. the most distinction within the moment research used to be the addition of an eight-day in depth in duction path. because of this new point, the relapse price used to be decreased considerably. one other results of the BFM-83 learn used to be the definition of 2 danger teams at the foundation of standardized therapy, which has bring about a risk-adapted therapy procedure within the 3rd ongoing trial, AML-BFM- 87. This development used to be in basic terms attainable due to the coop eration of pediatricians, physicians, radiotherapists, statisti cians, and particularly the employees on the hospitals and reference laboratories. therefore, we wish to thank every person who has been excited by those reviews and desire that they're going to be extra inspired to enhance remedy innovations for AML in young ones. The coordination, enforcement, and analyses of the stud ies do not need been attainable with out the monetary sup port of the Federal Ministry for learn and know-how of the FRG. we're thankful for the beneficiant contributions aiding this ebook from Lederle and Farmitalia. Munster, April 1990 Ursula Creutzig Jorg Ritter Gunther Schellong Contents 1 advent . . . . .. . . . . . . . . . . . . . . .. . . . 1 .
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Extra resources for Acute Myelogenous Leukemia in Childhood: Implications of Therapy Studies for Future Risk-Adapted Treatment Strategies
A Probability of survival after relapse in AML-BFM-78 vs. AML-BFM-83. b Probability of survival after relapse without BMT and with BMT in both studies combined. 4 Results by Morphologic Subtypes The results of the two studies by FAB types are listed in Table 18. In both studies, EDs due to hemorrhage and/or leukostasis, before or after onset of therapy, were mainly seen in monocytic leukemia (19/32, 59%) (compare Sect. ). Nonresponders occurred in all of the more frequent FAB types. en in the FAB types M2 and M4, unlike study AML-~fM-83, where they were most frequent in M5.
0 ........... 0 2 GIRLS BOYS N N -- 3 4 146 176 5 6 7 B 9 10 YEARS 5B IN CCR 76 IN CCR Fig. 19. Probability of EFS duration, girls vs. boys. 1 Influence of Sex in the FAB Types Table 20 shows the results by FAB types. 01). The difference in EFS (Fig. 13). In the FAB types M2 and M5, the EFS and BFI curves show no differences between girls and boys. Although there was a higher relapse rate in boys with FAB M4 (Fig. 18). B ~ II.. 6 ..... , .... /...........................................................................
O - - GIRLS ........... BOYS 2 N N - 3 37 36 4 5 6 7 B 9 10 YEARS 17 IN CCR 21 IN CCR Fig. 20. Probability of EFS duration in FAB MI, girls vs. boys. l0 FABMI FAB M2 FAB M4 FAB M5 Total F 94 91 75 74 84 M 70** 84 86 70 76 F 52 45 27 50 42 M 62 36 46 64 52 F M M F AML-BFM-78 AML-BFM-83 AML-BFM-78 AML-BFM-78/83 EFI (0/0) CR rate (0/0) 78 70 58 41 63 M 69 60 71 39 59 F AML-BFM-83 Table 20. , Q. 1119 ) .... \ .. /... :................................................ •••••••• BOYS N- N - 3 4 5 6 7 B YEARS 9 15 IN CCR 15 IN CCR 35 4B Fig.