Download Adenoviruses: Model and Vectors in Virus-Host Interactions: by G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. PDF

By G. E. Blair, M. E. Blair-Zajdel (auth.), Professor Dr. Walter Doerfler, Petra Böhm (eds.)

ISBN-10: 3642057152

ISBN-13: 9783642057151

After 3 volumes on adenoviruses in 1995 the previous years have obvious fast development within the box of adenovirus examine. furthermore, adenoviruses have attracted substantial curiosity as vectors in gene move regimens. After the 1st quantity on virion and constitution, viral replication and host-cell interplay this moment quantity bargains with the immune procedure, oncogenesis and gene remedy.

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Additional info for Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy

Sample text

Oncogene 12:143-151 Kushner DB, Ricciardi RP (1999) Reduced phosphorylation of p50 is responsible for diminished NF-/CB binding to the major histocompatibility complex class I enhancer in adenovirus type 12-transformed cells. Mol Cell BioI 19:2169-2179 Lankat-Biittgereit B, Tampe R (1999) The transporter associated with antigen processing TAP: structure and function. FEBS Letts 464:108-112 Li S, Paulsson KM, Chen S, Sjogren H-O, Wang P (2000) Tapasin is required for efficient peptide binding to transporter associated with antigen processing.

Lysosomal system (Gu and Gruenberg 1999) and have been proposed to be crucial for the biogenesis of so-called endocytic carrier vesicles, which are thought to transport proteins from early to late endosomes (Fig. 2). Not included in Table 2 are the various motifs implicated in targeting proteins to the apical membrane in polarized cells, such as N-glycans, O-glycans, TMDs, cytoplasmic peptides, and GPI-anchors (Rodriguez-Boulan and Gonzalez 1999). 2 YXX and Di-Leucine Motifs Sorting of numerous transmembrane proteins in the late secretory and endocytic pathways depends on YXX and di-Ieucine (LL) motifs in their cytoplasmic tails, and these motifs are also present in many adenovirus E3 proteins (see below).

1999; Kirchhausen 1999). The sequence requirements of YXX motifs for interaction with AP complexes have been investigated using combinatorial peptide libraries or the yeast-two-hybrid system. For the interaction with 112, a YXRL consensus motif was found in a combinatorial library approach (Boll et al. 1996). No preference for surrounding residues was observed. Applying the yeast-two-hybrid system, it was shown that mutations in the SDYQRL sequence of TGN38 affected its interactions with III and 112 differentially (Ohno et al.

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