By E. G. Snyderwine (auth.), Prof. Dr. med. Hans-Jörg Senn, Richard D. Gelber Ph.D, Prof. Dr. med. Aron Goldhirsch, Priv.-Doz. Dr. med. Beat Thürlimann (eds.)
This quantity presents an up to date survey of present laboratory and, in most cases, scientific examine at the diagnostic and therapies in fundamental breast melanoma. The chapters derive from the invited specialist lectures awarded on the sixth overseas convention on fundamental Breast melanoma held in St. Gallen, Switzerland, in February 1998. the global breast melanoma neighborhood has been eagerly watching for this quantity and its consensus platform and suggestions. there is not any replacement to this assembly and booklet within the box of adjuvant treatment of fundamental breast cancer.
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Additional resources for Adjuvant Therapy of Primary Breast Cancer VI
Chemoprevention is another important strategy against breast cancer which can and must be implemented, adopting a similar attitude to that which has been employed for a long time with encouraging results by cardiologists in their own field. The efficacy of the chemopreventive approach is based on a remarkably large host of solid data from the last 20 years. Along this line of research, studies on tamoxifen and fenretinide have lately provided encouraging results. Moreover, the combination of these two agents already demonstrated to be effective in preventing experimental breast cancer - looks quite promising, and a clinical trial is currently underway.
14 18 L[J[ D' I4 1' 0 x Fig. 1. Example of CGH analysis of microdissected paraffin-embedded lobular carcinoma in situ of the breast. The figure shows a profile of the average red-to-green fluorescence ratios from analysis of seven metaphase spreads. 2 smaller or greater than 1 indicated by the red and green vertical lines, respectively, is indicative of a copy number change. The heterochromatic regions adjacent to the centromeres are not informative. Gain of material from chromosome 1,5,11,14 and X and loss of regions from chromosomes 2,8,9,10,11,14 and 18 is indicated by this analysis.
Micronutrients that are considered to have protective potential against breast cancer are vitamin E and selenium (Knekt 1991; Osborne and Telang 1991). Use of nonsteroid anti-inflammatory drugs (such as sulindac), indole3-carbinol and aromatase inhibitors (such as vorozole) have been reported to be associated with reduced risk of breast cancer (He and Shut 1997; Lubet et al. 1997). Perhaps more importantly, new drugs are currently under evaluation which mimic the positive effects of estrogens on both bone and cardiovascular system without increasing the cancer risk for breast and uterus: these are the selective estrogen receptor modulators (SERMs).