By Herbert E. Spiegel (Eds.)
For greater than thirty years, this serial has broadened the technical scope and multiplied the medical base of medical chemistry. those volumes make clear the parts of molecular biology and informatics and the tracking of physiological parameters in severe occasions as they pertain to medical chemistry. each one quantity of Advances in scientific Chemistry includes an index, and every bankruptcy contains references.
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Extra resources for Advances in Clinical Chemistry, Vol. 36
It is possible to observe different types of inflammatory processes, which may indirectly suggest that this disease is present. Neuroborreliosis belongs among the diseases with the manifestation of serous inflammation; however, in the early stages of the disease, the findings may be quite different. The CEREBROSPINAL FLUID 41 reason for their less frequent detection is that often the development of the disease is not apparent and the cerebrospinal fluid is examined only after the early stage of the disease has subsided.
An increase in the IgM index is usually associated with oligoclonal IgM bands on electrophoresis. This indicates an oligoclonal aspect of intrathecally produced IgM. Cerebral IgM production is related to the activity of multiple sclerosis, and the early detection of oligoclonal IgM in patients with acute isolated lesions of the brainstem and spinal cord has more predictive value for the development of multiple sclerosis than does detection of oligoclonal IgG bands (L1). 3. EVALUATION OF THE INTRATHECAL SYNTHESIS OF IMMUNOGLOBULIN G The absolute value of the IgG concentration in CSF depends on the IgG concentration in serum, blood–brain barrier function, age of the patient, volume of CSF extracted, and local IgG synthesis in the central nervous system.
5. IgM. A large body of literature on the monitoring of IgM levels in cerebrospinal fluid is currently available, addressing topics such as autoimmune disease, multiple sclerosis, infectious diseases of the central nervous system, and dementias. Although most groups of patients described are large enough, what is badly needed is a comparison of IgM with the behavior of other protein fractions in CSF in statistically appropriate groups. To date, no convincing correlations with cytological CSF findings have been demonstrated.